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IL-27Rα Rat anti-Mouse, PE, Clone: 2918, BD

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 564337

Catalog No. BDB564337


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Description

Description

The 2918 monoclonal antibody specifically binds to the alpha subunit (IL-27 Receptor alpha/IL-27 R α ) of the mouse Interleukin-27 Receptor complex. IL-27 R α is a type I transmembrane glycoprotein that belongs to the type I cytokine receptor family. It is also known as WSX-1 and T cell cytokine receptor (TCCR). IL-27 R α combines with gp130 (CD130) to form a high-affinity cell surface receptor that transduces intracellular signals through the JAK-STAT pathway upon IL-27 binding. IL-27 is a heterodimeric cytokine that is composed of the Epstein-Barr virus-induced gene 3 (EBI3) and IL-27p28 (IL-30) protein subunits. This multifunctional cytokine is produced by activated macrophages, dendritic cells, and epithelial cells. It mediates a broad array of pro- and anti-inflammatory responses. The IL-27 Receptor is expressed by a variety of cell types including naοve T cells and B cells. It is more highly expressed by NK cells and subsets of activated T cells.

Specifications

Specifications

IL-27Rα
2918
PE
Aqueous buffered solution containing ≤0.09% sodium azide.
Rat
IgG2a, κ
RUO
Primary
Murine
Flow Cytometry
0.2mg/mL
Il27ra; IL-27-R; IL-27Rα; T cell cytokine receptor; TCCR; WSX-1; CRL1
Affinity Purified
Mouse TSRR Transfected Cell Line
50μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
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