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MilliporeSigma™ anti-IL-4 APC, Clone: 11B11,

Catalog No. MABF1503MI Shop All MilliporeSigma Products
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MABF1503MI 25 μg
MABF1504MI 100 μg
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Catalog No. MABF1503MI Supplier MilliporeSigma™ Supplier No. MABF1503
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Description

Rat Monoclonal Antibody

Specifically detects IL-4 Clone: 11B11 in Mouse samples, and it is validated for Flow Cytometry

The 11B11 antibody binds to mouse Interleukin-4 (IL-4), a 14kDa cytokine that is largely secreted by activated T cells of the Th2 subset, and to some degree by NKT and mast cells. This cytokine acts as a stimulatory factor for B cells, inducing their proliferation and differentiation, as well as playing a role in immunoglobulin class-switching. IL-4 may also provide autocrine stimulation for T cells, and affect the function of antigen presenting cells such as macrophages and dendritic cells. IL-4 can bind and signal via three cell surface receptor types: CD124 by itself, CD124 in combination with the common gamma chain (type I complex), or CD124 combined with CD213a1 (type II complex).The 11B11 antibody is widely used for detection of intracellular levels of IL-4 protein by flow cytometry, as well as for analysis of soluble cytokine as measured by ELISA, and in functional assays to neutralization cytokine-receptor interactions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IL-4
Applications Flow Cytometry
Classification Monoclonal
Clone 11B11
Conjugate APC
Formulation Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Accession No. P07750
Gene Symbols Il4, Il-4
Host Species Rat
Immunogen Proprietary immunogen
Purification Method Purified by size-exclusion chromatography
Quantity 25 μg
Regulatory Status RUO
Research Discipline Inflammation, Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage 2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Form Purified
Isotype IgG1 κ
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For Research Use Only

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