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IL-5 Rat anti-Human, NA/LE, Unlabeled, Clone: JES1-5A10, BD

Catalog No. BDB562175 Shop All BD Biosciences Products
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BDB562175 0.5 mg
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Catalog No. BDB562175 Supplier BD Biosciences Supplier No. 562175
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Description

Rat Monoclonal Antibody

The JES1-5A10 monoclonal antibody specifically binds to the human Interleukin-5 (IL-5). IL-5 is a cytokine that is also known as T-cell replacing factor (TRF), Eosinophil differentiation factor (EDF), and B cell differentiation factor I. IL-5 is produced by T cells, mast cells, and eosinophils. IL-5 controls the generation, differentiation, activation and localization of eosinophils. IL-5 also activates and promotes the differentiation of basophils. IL-5 plays an important role in regulating cell-mediated immunity against parasitic infections and some tumors. High level IL-5 production is involved in some allergic diseases including asthma. IL-5 exerts its biological effects by binding to and signaling through high-affinity heterodimeric IL-5 receptors comprised of transmembrane IL-5 receptor alpha (IL-5R α, aka, CD125) and beta common (βc, aka, CD131) chains. The βc chain serves as the common signaling subunit for the IL-5 receptor heterodimer as well as for the heterodimeric IL-3 and GM-CSF receptors. The immunogen used to generate the JES1-5A10 hybridoma was recombinant human IL-5. The JES1-5A10 antibody has been reported to cross react with IL-5 from rhesus monkey. This is a neutralizing antibody.

TRUSTED_SUSTAINABILITY

Specifications

Antigen IL-5
Applications ELISA
Classification Monoclonal
Clone JES1-5A10
Concentration 1.0mg/mL
Conjugate Unconjugated
Description EDF; Eosinophil differentiation factor; TRF; T-cell replacing factor
Formulation No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
Host Species Rat
Immunogen Recombinant Human IL-5
Purification Method Affinity Purified
Quantity 0.5 mg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C
Isotype IgG2a
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