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Invitrogen™ IL5RA Monoclonal Antibody (26815), PE
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA523621
Description
In direct ELISAs and Western blots, this antibody does not cross-react with recombinant human (rh) IL-5 R beta, rhIL-9 R, rhIL-4 R, recombinant mouse IL-5 R alpha, or rhIL-13 R alpha 1.
Interleukin 5 (IL-5) is a soluble T cell-derived factor, also known as T cell replacing factor (TRF), that induces B cell and eosinophil growth and differentiation. IL-5 exerts its biological activity through the IL-5 receptor (IL-5R), which is composed of two chains: an alpha chain that binds IL-5 with low affinity and a beta chain that does not bind IL-5, but together with the IL-5 alpha chain, constitutes the high affinity IL-5 receptor. The cytoplasmic domain of both the alpha and beta chains is essential for signal transduction. Specifically, the membrane-proximal proline-rich sequence of the cytoplasmic domain of the IL-5R receptor alpha subunit, IL-5Ralpha, is critical for the IL-5 induced proliferative response, expression of nuclear proto-oncogenes and tyrosine phosphorylation of cellular proteins, such as JAK1 and JAK2.
Specifications
IL5RA | |
Monoclonal | |
PE | |
IL5RA | |
CD125; CD125 antigen; CDw125; HSIL5R3; IL-5 receptor alpha chain; IL-5 receptor subunit alpha; Il5r; IL-5R subunit alpha; Il5ra; IL-5RA; IL-5R-alpha; interleukin 5 receptor subunit alpha; interleukin 5 receptor type 3; interleukin 5 receptor, alpha; interleukin-5 receptor alpha chain; interleukin-5 receptor subunit alpha | |
Mouse | |
Protein A/G | |
RUO | |
3568 | |
4°C, store in dark, DO NOT FREEZE! | |
Liquid |
Flow Cytometry | |
26815 | |
Buffered saline solution with BSA and 0.09% sodium azide | |
Q01344 | |
IL5RA | |
Sf 21-derived recombinant human IL-5R alpha/CD125 Asp21-Arg335. | |
100 Tests | |
Primary | |
Human | |
Antibody | |
IgG1 |
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