Invitrogen™ IL5RA Monoclonal Antibody (26815), PE

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA523621

Catalog No. PIMA523621

Description

In direct ELISAs and Western blots, this antibody does not cross-react with recombinant human (rh) IL-5 R beta, rhIL-9 R, rhIL-4 R, recombinant mouse IL-5 R alpha, or rhIL-13 R alpha 1.

Interleukin 5 (IL-5) is a soluble T cell-derived factor, also known as T cell replacing factor (TRF), that induces B cell and eosinophil growth and differentiation. IL-5 exerts its biological activity through the IL-5 receptor (IL-5R), which is composed of two chains: an alpha chain that binds IL-5 with low affinity and a beta chain that does not bind IL-5, but together with the IL-5 alpha chain, constitutes the high affinity IL-5 receptor. The cytoplasmic domain of both the alpha and beta chains is essential for signal transduction. Specifically, the membrane-proximal proline-rich sequence of the cytoplasmic domain of the IL-5R receptor alpha subunit, IL-5Ralpha, is critical for the IL-5 induced proliferative response, expression of nuclear proto-oncogenes and tyrosine phosphorylation of cellular proteins, such as JAK1 and JAK2.

Specifications

• Antigen: IL5RA
• Classification: Monoclonal
• Conjugate: PE
• Gene: IL5RA
• Gene Alias: CD125; CD125 antigen; CDw125; HSIL5R3; IL-5 receptor alpha chain; IL-5 receptor subunit alpha; Il5r; IL-5R subunit alpha; Il5ra; IL-5RA; IL-5R-alpha; interleukin 5 receptor subunit alpha; interleukin 5 receptor type 3; interleukin 5 receptor, alpha; interleukin-5 receptor alpha chain; interleukin-5 receptor subunit alpha
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 3568
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Form: Liquid

• Applications: Flow Cytometry
• Clone: 26815
• Formulation: Buffered saline solution with BSA and 0.09% sodium azide
• Gene Accession No.: Q01344
• Gene Symbols: IL5RA
• Immunogen: Sf 21-derived recombinant human IL-5R alpha/CD125 Asp21-Arg335.
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1