IL5RA Mouse anti-Human, PE, Clone: 26815, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523621

Catalog No. PIMA523621

Description

In direct ELISAs and Western blots, this antibody does not cross-react with recombit human (rh) IL-5 R beta, rhIL-9 R, rhIL-4 R, recombit mouse IL-5 R alpha, or rhIL-13 R alpha 1.

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported.

Specifications

• Antigen: IL5RA
• Classification: Monoclonal
• Conjugate: PE
• Gene: IL5RA
• Format: Liquid
• Gene Symbols: IL5RA
• Immunogen: Sf 21-derived recombit human IL-5R alpha/CD125 Asp21-Arg335
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Human

• Applications: Flow Cytometry
• Clone: 26815
• Formulation: Buffered saline solution with BSA and 0.09% sodium azide
• Gene Accession No.: Q01344
• Gene Alias: CD125, CDw125, HSIL5R3, IL5R, CD125 antigen, IL-5 receptor subunit alpha, IL-5R subunit alpha, interleukin 5 receptor type 3, interleukin-5 receptor alpha chain, interleukin-5 receptor subunit alpha
• Host Species: Mouse
• Isotype: IgG1
• Quantity: 100 Tests
• Storage Requirements: 4° C, store in dark, DO NOT FREEZE!
• Primary or Secondary: Primary
• Gene ID (Entrez): 3568