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iNOS Mouse anti-Mouse, Unlabeled, Clone: 2, BD
Mouse Monoclonal Antibody
Specifications
| Antigen | iNOS |
|---|---|
| Clone | 2 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|
BDB610600
|
BD Biosciences
610600 |
150 μg | Item Discontinued This item has been discontinued by the manufacturer and is no longer available. Please reach out to your sales representative. | N/A | |||||
|
BDB610599
|
BD Biosciences
610599 |
50 μg | Item Discontinued This item has been discontinued and is no longer available. Please reach out to your sales representative. | N/A | |||||
Description
Nitric oxide synthase (NOS), a cell-type specific enzyme, catalyzes the synthesis of nitric oxide (NO). NO is a short-lived radical that transmits cellular signals involved in vasorelaxation, neurotransmission, and cytotoxicity. In macrophages and other cell types, NOS (iNOS or macNOS) activity increases following exposure to cytokines (IFN-γ, TNF-α, and IL-1) and microbial products (lipopolysaccharide (LPS)). iNOS isactivated independently of Ca2+/calmodulin and its level of expression is tightly controlled by several transcription factors, including NFκB. Data indicates that TGF-β affects translation of iNOS mRNA and decreases iNOS protein stability. Normally undetectable in brain tissue, iNOS mRNA has been observed in CNS tissues of animals under experimental pathologic conditions. iNOS and nNOS share 51% amino acid homology with the greatest degree of divergence in the calmodulin binding domain.
Immunofluorescence, Immunoprecipitation, Western Blotting
Specifications
| iNOS | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified | |
| NOS Type II |
| 2 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Mouse | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.
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