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iNOS Mouse anti-Mouse, Unlabeled, Clone: 54, BD

Mouse Monoclonal Antibody

$287.50 - $568.50

Specifications

Antigen iNOS
Clone 54
Concentration 250μg/mL
Applications Western Blot
Classification Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610431
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BD Biosciences
610431
50 μg
Each for $287.50
Only null left
Add to Cart
 
BDB610432
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BD Biosciences
610432
150 μg
Each for $568.50
Only null left
Add to Cart
 
Description

Description

Nitric oxide synthase (NOS), a cell-type specific enzyme, catalyzes the synthesis of nitric oxide (NO). NO is a short-lived radical that transmits cellular signals involved in vasorelaxation, neurotransmission, and cytotoxicity. In macrophages and other cell types, NOS (iNOS or macNOS) activity increases following exposure to cytokines (IFN-γ, TNF-α, and IL-1) and microbial products (lipopolysaccharide (LPS)). iNOS is activated independently of Ca2+/calmodulin and its level of expression is tightly controlled by several transcription factors, including NFκB. Data indicates that TGF-β affects translation of iNOS mRNA and decreases iNOS protein stability. Normally undetectable in brain tissue, iNOS mRNA has been observed in CNS tissues of animals under experimental pathologic conditions. iNOS and nNOS share 51% amino acid homology with the greatest degree of divergence in the calmodulin binding domain. This antibody has been reported to cross-react with nNOS and eNOS.

Immunofluorescence, Immunoprecipitation, Western Blotting

Specifications

Specifications

iNOS
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG2a κ
Affinity Purified
NOS Type II
54
Western Blot
Unconjugated
RUO
Mouse
IgG2a, κ
Primary
Store undiluted at -20°C.
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