Integrin β7 Rat, Brilliant Violet 421, Clone: FIB504, BD

Rat Monoclonal Antibody

Supplier:  BD Biosciences 564283

Catalog No. BDB564283

Description

FIB504 reacts with mouse integrin β 7 subunit (130 kD) but also cross reacts with human integrin β 7. Integrin β 7 associates with α 4 (CD49d) expressed on subsets of lymphocytes and thymus. It also associates with α IEL (CD103) expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Integrin β 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response.

The antibody was conjugated to BD Horizon™ BV421 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 407-nm and Em Max at 421-nm, BD Horizon BV421 can be excited by the violet laser and detected in the standard Pacific Blue™ filter set (eg, 450/50-nm filter). BD Horizon BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates.

Specifications

• Antigen: Integrin β7
• Classification: Monoclonal
• Conjugate: Brilliant Violet 421
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide
• Immunogen: Mouse T lymphoma line TK1
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: FIB504
• Description: Itgb7; Integrin β7; Integrin beta 7; ITB7; Ly-69; Ly69
• Host Species: Rat
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human, Mouse
• Isotype: IgG2b κ