Integrin b7 chain Rat anti-Mouse, PE, Clone: M293, BD

Rat Monoclonal Antibody

Supplier:  BD Biosciences 557498

Catalog No. BDB557498

Description

The M293 antibody reacts with the integrin β7 chain (also known as integrin βp), which is found in association with either of two α chains. α4β7 (LPAM-1) is expressed on most mature lymphocytes and on small subsets of thymic and bone marrow cells; it interacts with several ligands, including VCAM-1, fibronectin, and MAdCAM-1. αIELβ7 is found primarily on intestinal mucosal and intraepithelial lymphocytes (IEL), and it may be primarily involved in interactions between IEL and epithelia via recognition of E-cadherin. The epitope recognized by the mAb M293 has been mapped to the region between amino acids 387 and 542. The M293 antibody exhibits little or no activity in blocking β7 integrin-mediated adhesion.

Host Species: Rat
Clone: M293
Isotype: IgG2a, κ
Species Reactivity: Mouse
Immunogen: <special id='301'/>IEL<special id='302'/>7 integrin from the C57BL/10 mouse T-cell hybridoma MTC-1

Flow Cytometry

Specifications

• Antigen: Integrin b7 chain
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Description: Integrin βp
• Host Species: Rat
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: M293
• Conjugate: PE
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: αIELβ7 integrin from the C57BL/10 mouse T-cell hybridoma MTC-1
• Quantity: 0.1 mg
• Research Discipline: Immunology
• Target Species: Mouse
• Isotype: IgG2a κ

For Research Use Only.