CD41 Mouse anti-Human, Non-human primate, Clone: HIP2, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119382
This antibody reacts with beta (b) subunit of CD41 glycoprotein (light chain; 23 kDa).CD41 (platelet glycoprotein IIb, ITGA2B) is composed of two subunits -120 kDa a, alpha and 23 kDa b, beta- that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. CD41 is also involved in blood coagulation by mediating platelet aggregation. Upon blood vessel damage, CD41 binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during the early stages of hematopoietic differentiation. Diseases associated with CD41 dysfunction include Glansmann Thrombasthenia, and Platelet type-16 bleeding disorder.
|Human, Non-human Primate|
|Flow Cytometry, Immunohistochemistry (Frozen)|
|TBS with 15mM sodium azide; pH 8.0|
|BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, GPalpha IIb, integrin alpha-IIb, platelet fibrinogen receptor, alpha subunit, platelet membrane glycoprotein IIb, platelet-specific antigen BAK, ITGA2B|
|4° C, do not freeze|
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