Integrin beta 7 Mouse anti-Human, FITC, Clone: 473207, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA523592
In Western blots, no cross-reactivity with recombit human Integrin beta 1, beta 2, beta 3, beta 4, beta 5, beta 6, beta 8, recombit mouse Integrin beta 4, or beta 7 is observed.Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Ligands for LPAM-1 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the ligand of HML-1 is E-cadherin (CD324). Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response.
|Integrin beta 7|
|CHO-derived recombit human Integrin beta 7 long isoform Glu20-His723|
|Buffered saline solution with BSA and 0.09% sodium azide|
|Integrin beta-7, Gut homing receptor beta subunit, ITGB7|
|4° C, store in dark, DO NOT FREEZE!|
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