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MilliporeSigma™ anti-Integrin beta1 Clone: 4B7,

Catalog No. CP26100UG Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
CP26100UG 100 μg Unconjugated
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Catalog No. CP26100UG Supplier MilliporeSigma™ Supplier No. CP26100UG

Description

Mouse Monoclonal Antibody

Specifically detects Integrin β1 Clone: 4B7 in Human samples, and it is validated for Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Neutralization

The integrins are a family of more than 23 heterodimeric transmembrane proteins that mediate cell-cell adhesions as well as cell-substratum adhesions and signal transduction processes. Expressed on essentially all cells as an alpha-beta dimeric protein, alterations in the integrin structure leading to changes in adhesive properties have important implications for tumor invasiveness and progression. The majority of the protein is found in the globular extracellular domain with the intracellular domain only composed of 60 amino acids or less. The beta 1 integrin is found widely distributed and is one of the subunits composing the major fibronectin receptor (FNR) along with the alpha 5 integrin. The beta 1 integrin has been shown to have a direct as well as a regulatory role in ligand binding and subsequent signal transduction. Upon ligand binding there is initiated a signal transduction cascade involving the phosphorylation of the integrin molecule itself as well as any of a number of different substrates including pp125FAK, PLCγ, MAP kinase and others. In addition to the role played in normal cell-cell interactions and development, integrins play an important role in the etiology of cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Integrin β1
Applications Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Neutralization
Classification Monoclonal
Clone 4B7
Conjugate Unconjugated
Formulation In 50mM sodium phosphate buffer, 50% glycerol.
Host Species Mouse
Immunogen recombinant, human β1 integrin
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the β1 integrin subunit in A431 and Jurkat cells.
Target Species Human
Content And Storage −20°C
Form Purified
Isotype IgG1
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