IP3R-3 Mouse, Unlabeled, Clone: 2, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 610313

Catalog No. BDB610313

Description

Inositol 1,4,5-triphosphate (IP3) functions as a second messenger for many hormones, growth factors, and neurotransmitters. IP3 causes the release of Ca²⁺ from intracellular stores by binding specific receptors that are coupled to Ca²⁺ channels. A number of studies have identified a family of at least four IP3 receptors (IP3R). The type III receptor (IP3R-3) has been isolated and characterized in human and rat. IP3 receptors are commonly localized in the endoplasmic reticulum, but have also been identified in the nucleus and the plasma membrane. Co-expression of different IP3 receptors is detected in most tissues and cell lines. Although these receptors appear to have a similar specificity for inositol phosphates, the different receptors have been reported to have different affinities for IP3 as follows: type II > type I > type III.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

• Antigen: IP3R-3
• Classification: Monoclonal
• Concentration: 250μg/mL
• Description: Inositol 1,4,5-triphosphate receptor type III
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

• Applications: Western Blot
• Clone: 2
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Immunogen: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Quantity: 150 μg
• Research Discipline: Cell Biology
• Target Species: Bovine, Canine, Human, Mouse, Rat
• Isotype: IgG2a

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.