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Importin 7 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA525349

Catalog No. PIPA525349

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran ft.s GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.
Specifications

Specifications

Importin 7
Polyclonal
PBS with 0.09% sodium azide
O95373, Q9EPL8
Imp7, RANBP7, RAN-binding protein 7, importin-7
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
10527, 233726
Immunohistochemistry, Western Blot
Unconjugated
IPO7
Liquid
IPO7
KLH conjugated synthetic peptide between 142-169 amino acids from the N-terminal region of human IPO7
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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