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IRE1 alpha Rabbit anti-Human, Mouse, Rat, HRP, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA522727

Catalog No. PIPA522727


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Description

Description

This antibody does not react with non-human primate samples. Suggested positive control: Pancreatic islets and insulinoma cells.

IRE1 alpha is the endoplasmic reticulum to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. IRE1 alpha protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. Specifically, IRE1 acts as the sensor of unfolded proteins in the ER that initiates transmittance of the unfolded protein signal from the ER to the nucleus by splicing XBP1 mRNA converting it into a potent unfolded-protein response transcriptional activator. Null mutants are viable, but IRE1 is essential for viability under stress conditions that cause unfolded proteins to accumulate in the ER. Depletion of IRE1p through the expression of a domit negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER.
Specifications

Specifications

IRE1 alpha
Polyclonal
HRP
ERN1
Liquid
ERN1
A synthetic peptide within the human IRE1 alpha protein (within residues 700-800).
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with no preservative
O75460, Q9EQY0
IRE1, IRE1P, IRE1a, hIRE1p, ER to nucleus signalling 1, endoplasmic reticulum-to-nucleus signaling 1, inositol-requiring 1, inositol-requiring enzyme 1, inositol-requiring protein 1, ire1-alpha, protein kinase/endoribonuclease, serine/threonine-protein kinase/endoribonuclease IRE1
Rabbit
IgG
100 μL
4° C, store in dark
Primary
2081, 498013, 78943
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