ITK Mouse, Unlabeled, Clone: 2F12, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 550503

Catalog No. BDB550503

Description

Itk (IL-2 inducible tyrosine kinase) is a member of the TEC family of intracellular tyrosine kinases. Members of this family are characterized by their role in hematopoietic cell signaling. Itk is expressed primarily in T cells and has been shown to play a role in T-cell antigen receptor (TCR) mediated proliferation, interleukin-2 production, and T cell differentiation. Itk, following stimulation of the TCR becomes phosphorylated on tyrosine 511 by the Src kinase Lck resulting in increased in vitro Itk kinase activity. If phenylalanine is substituted for tyrosine at position 511, the in vivo kinase activity of Itk is drastically diminished, indicating that this site plays a key role in regulating Itk function. Itk migrates at ∽72kDa on SDS/PAGE. (SWISSPROT: Q08881)

Host Species: Mouse
Clone: 2F12
Isotype: IgG1
Species Reactivity: Human
Immunogen: Fusion protein with aa.1-26 of human/mouse Itk

Immunoprecipitation, Western Blotting

Specifications

• Antigen: ITK
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Fusion protein with aa.1-26 of human/mouse Itk
• Quantity: 50 μg
• Research Discipline: Cell Biology
• Target Species: Human, Mouse
• Isotype: IgG1

• Applications: Western Blot
• Clone: 2F12
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.