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MilliporeSigma™ anti-JAK2, Polyclonal

Rabbit Polyclonal Antibody

Manufacturer:  MilliporeSigma™ 06255I

Catalog No. 06-255-IMI


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Description

Description

Specifically detects JAK2 Clone: in Human, Mouse, Rat samples, and it is validated for Immunoprecipitation, Western Blotting

Tyrosine-protein kinase JAK2 (EC 2.7.10.2; UniProt Q62120; also known as JAK-2, Janus kinase 2) is encoded by the Jak2 (also known as Fd17) gene (Gene ID 16452) in murine species. JAK2 belongs to the family of non-receptor Janus tyrosine kinases that regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines cause the recruitment of Stat transcription factors to cytokine receptor. Subsequent phosphorylation by receptor-associated JAK2 causes Stat dimerization, nuclear translocation, and Stat-mediated target genes transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Altering JAK/Stat signaling to reduce immune cells cytokine responses represents an attractive target for anti-inflammatory therapies. Within the JAK2 kinase domain, there is a region that has considerable sequence homology to the regulatory region of the insulin receptor.
Specifications

Specifications

JAK2
Unconjugated
Q62120
Jak2
KLH-conjugated linear peptide corresponding to residues 758-776 of mouse JAK2.
100μg
Signaling
Primary
NP_001041642
Immunoprecipitation, Western Blot
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Purified
Rabbit
Protein A purified
RUO
2°C to 8°C for one year
Polyclonal
Human, Murine, Rat
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