MilliporeSigma anti-JAK2, Polyclonal
Rabbit Polyclonal Antibody
Manufacturer: MilliporeSigma 06255I
Specifically detects JAK2 Clone: in Human, Mouse, Rat samples, and it is validated for Immunoprecipitation, Western BlottingTyrosine-protein kinase JAK2 (EC 220.127.116.11; UniProt Q62120; also known as JAK-2, Janus kinase 2) is encoded by the Jak2 (also known as Fd17) gene (Gene ID 16452) in murine species. JAK2 belongs to the family of non-receptor Janus tyrosine kinases that regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines cause the recruitment of Stat transcription factors to cytokine receptor. Subsequent phosphorylation by receptor-associated JAK2 causes Stat dimerization, nuclear translocation, and Stat-mediated target genes transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Altering JAK/Stat signaling to reduce immune cells cytokine responses represents an attractive target for anti-inflammatory therapies. Within the JAK2 kinase domain, there is a region that has considerable sequence homology to the regulatory region of the insulin receptor.
|KLH-conjugated linear peptide corresponding to residues 758-776 of mouse JAK2.|
|Immunoprecipitation, Western Blot|
|Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.|
|Protein A purified|
|2°C to 8°C for one year|
|Human, Murine, Rat|
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