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JAML Armenian Hamster anti-Mouse, PE, Clone: 4E10 (also known as HL4E10), BD

Catalog No. BDB564218 Shop All BD Biosciences Products
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BDB564218 50 μg
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Catalog No. BDB564218 Supplier BD Biosciences Supplier No. 564218

Description

Armenian Hamster Monoclonal Antibody

The 4E10 monoclonal antibody specifically binds to Junctional Adhesion Molecule-Like (JAML) which is also known as JAML1, AMICA, Amica1, Crea7, mCrea7, and Gm638. JAML is a type I transmembrane glycoprotein whose extracellular region contains two immunoglobulin domains. The 4E10 antibody binds to the membrane-proximal D2 Ig domain of JAML which is expressed on g ranulocytes, monocytes, memory T cells and γδ T cells. JAML serves as an endogenous ligand for epithelial and endothelial Coxsackie and Adenovirus Receptor (CAR). The JAML-CAR interaction supports leucocyte migration and the costimulation of TCR-triggered epithelial γδ T cells. The 4E10 antibody can induce costimulatory signals through JAML leading to increased activation, cytokine production and proliferation by epithelial γδ T cells.

TRUSTED_SUSTAINABILITY

Specifications

Antigen JAML
Applications Flow Cytometry
Classification Monoclonal
Clone 4E10 (also known as HL4E10)
Concentration 0.2mg/mL
Conjugate PE
Description JAML1; AMICA; Amica1; Crea7; mCrea7; Gm638
Host Species Armenian Hamster
Immunogen Mouse Skin γδ T Cell Line
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG
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