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JAML Armenian Hamster anti-Mouse, PE, Clone: 4E10 (also known as HL4E10), BD
Armenian Hamster Monoclonal Antibody
Manufacturer: BD Biosciences 564218
The 4E10 monoclonal antibody specifically binds to Junctional Adhesion Molecule-Like (JAML) which is also known as JAML1, AMICA, Amica1, Crea7, mCrea7, and Gm638. JAML is a type I transmembrane glycoprotein whose extracellular region contains two immunoglobulin domains. The 4E10 antibody binds to the membrane-proximal D2 Ig domain of JAML which is expressed on g ranulocytes, monocytes, memory T cells and γδ T cells. JAML serves as an endogenous ligand for epithelial and endothelial Coxsackie and Adenovirus Receptor (CAR). The JAML-CAR interaction supports leucocyte migration and the costimulation of TCR-triggered epithelial γδ T cells. The 4E10 antibody can induce costimulatory signals through JAML leading to increased activation, cytokine production and proliferation by epithelial γδ T cells.
|4E10 (also known as HL4E10)|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|JAML1; AMICA; Amica1; Crea7; mCrea7; Gm638|
|Mouse Skin γδ T Cell Line|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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