JAML Armenian Hamster anti-Mouse, PE, Clone: 4E10 (also known as HL4E10), BD

Armenian Hamster Monoclonal Antibody

Supplier:  BD Biosciences 564218

Catalog No. BDB564218

Description

The 4E10 monoclonal antibody specifically binds to Junctional Adhesion Molecule-Like (JAML) which is also known as JAML1, AMICA, Amica1, Crea7, mCrea7, and Gm638. JAML is a type I transmembrane glycoprotein whose extracellular region contains two immunoglobulin domains. The 4E10 antibody binds to the membrane-proximal D2 Ig domain of JAML which is expressed on g ranulocytes, monocytes, memory T cells and γδ T cells. JAML serves as an endogenous ligand for epithelial and endothelial Coxsackie and Adenovirus Receptor (CAR). The JAML-CAR interaction supports leucocyte migration and the costimulation of TCR-triggered epithelial γδ T cells. The 4E10 antibody can induce costimulatory signals through JAML leading to increased activation, cytokine production and proliferation by epithelial γδ T cells.

Specifications

• Antigen: JAML
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Description: JAML1; AMICA; Amica1; Crea7; mCrea7; Gm638
• Immunogen: Mouse Skin γδ T Cell Line
• Quantity: 50 μg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: 4E10 (also known as HL4E10)
• Conjugate: PE
• Host Species: Armenian Hamster
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Mouse
• Isotype: IgG