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JIP-1 Mouse, Unlabeled, Clone: 50, BD

Catalog No. BDB611890 Shop All BD Biosciences Products
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BDB611890 50 μg
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Catalog No. BDB611890 Supplier BD Biosciences Supplier No. 611890

Description

Mouse Monoclonal Antibody

The JNK group of MAPKs is activated by a variety of inflammatory cytokines and environmental stressors. Activated JNK phosphorylates many cellular proteins, such as components of the AP-1 transcription factor complex (c-Jun and ATF-2). JNK-interacting proteins (JIPs) bind JNK, MKK7, MLKs, p190RhoGEF, and the Ste20-related protein kinase HPK1. In mouse, alternative splicing of JIP produces multiple splice variants, JIP-1, JIP-1b, JIP-2a, JIP-2b, and JIP-3. The structure of full length JIP consists of two N-terminal acidic regions, a JNK binding domain (JBD), two proline rich regions (PR), and both an SH3 and a phosphotyrosine-binding domain in the C-terminal region. JIP-1 localizes to the tips of neurites in differentiated PC12 cells, and may interact with JNK, MKK7, and MLK to facilitate formation of the JNK activating complex. IB1 is the rat homologue of JIP-1b, a JIP-1 variant that includes a 47 amino acid insert in the C-terminal region. IB1 is found in the nucleus and cytoplasm, and may function as a transactivator of the GLUT2 gene. Thus, JIP-1 and its related isoforms may have multiple functions that involve specific protein-protein interactions.

Host Species: Mouse
Clone: 50
Isotype: IgG1
Species Reactivity [for Features Main]: Mouse
Immunogen: Mouse JIP-1 aa. 180-384

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen JIP-1
Applications Western Blot
Classification Monoclonal
Clone 50
Concentration 250μg/mL
Conjugate Unconjugated
Description JNK Interacting Protein
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Mouse JIP-1 aa. 180-384
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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For Research Use Only.

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