Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Kanadaptin Mouse, Unlabeled, Clone: 49, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611155

Catalog No. BDB611155

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

The erythroid anion exchanger (AE1, band 3) is a membrane protein that, through its large cytoplasmic domain, binds to ankyrin and helps maintain the biconcave shape of erythrocytes. The alternatively spliced, kidney-specific isoform of AE1 (kAE1) can be retargeted from the apical to the basolateral surface of intercalated cells. However, kAE1 lacks a portion of the AE1 cytoplasmic domain and does not interact with ankyrin. Efforts to identify kAE1-binding proteins led to the discovery of kanadaptin (kidney anion exchanger adaptor protein) .
Kanadaptin binds specifically to kAE1 and does not interact with either erythroid AE1 or ankyrin. Although kAE1 is present in intracellular vesicles and basolateral membranes, it colocalizes with kanadaptin exclusively in vesicles. Thus, it is thought that kanadaptin may shuttle kAE1-containing vesicles to their destination at the basolateral membrane and then dissociate and recycle. This idea is supported by the presence of a proline-rich region in kanadaptin that may serve as an SH3-binding domain and mediate protein-protein interactions. The presence of kanadaptin in various tissues suggests other roles which have yet to be described.

Host Species: Mouse
Clone: 49
Isotype: IgG1
Species Reactivity: Human, Rat, Mouse
Immunogen: Mouse Kanadaptin aa. 60-171
Formula Weight [Chemical]: 53kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

Kanadaptin
49
Unconjugated
Murine
IgG1
RUO
Primary
Human, Murine, Rat
Immunofluorescence, Western Blot
250μg/mL
Affinity Purified
Mouse Kanadaptin aa. 60-171
150μg
Cell Biology
Monoclonal
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit