Kanadaptin Mouse, Unlabeled, Clone: 49, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611155
The erythroid anion exchanger (AE1, band 3) is a membrane protein that, through its large cytoplasmic domain, binds to ankyrin and helps maintain the biconcave shape of erythrocytes. The alternatively spliced, kidney-specific isoform of AE1 (kAE1) can be retargeted from the apical to the basolateral surface of intercalated cells. However, kAE1 lacks a portion of the AE1 cytoplasmic domain and does not interact with ankyrin. Efforts to identify kAE1-binding proteins led to the discovery of kanadaptin (kidney anion exchanger adaptor protein) .
Kanadaptin binds specifically to kAE1 and does not interact with either erythroid AE1 or ankyrin. Although kAE1 is present in intracellular vesicles and basolateral membranes, it colocalizes with kanadaptin exclusively in vesicles. Thus, it is thought that kanadaptin may shuttle kAE1-containing vesicles to their destination at the basolateral membrane and then dissociate and recycle. This idea is supported by the presence of a proline-rich region in kanadaptin that may serve as an SH3-binding domain and mediate protein-protein interactions. The presence of kanadaptin in various tissues suggests other roles which have yet to be described.
Host Species: Mouse
Species Reactivity: Human, Rat, Mouse
Immunogen: Mouse Kanadaptin aa. 60-171
Formula Weight [Chemical]: 53kDa
Immunofluorescence, Western Blotting
|Human, Murine, Rat|
|Immunofluorescence, Western Blot|
|Mouse Kanadaptin aa. 60-171|
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