potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3, Mouse, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-004-181	50 μL

Catalog No. 89-004-181 Supplier Abnova Corporation Supplier No. H00003782A01

Description

Mouse polyclonal antibody raised against a partial recombinant KCNN3.

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding two different isoforms have been found for this gene. One of the variants lacks the CAG repeat regions. [provided by RefSeq

Sequence: QAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIG

Specifications

• Antigen: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Mouse polyclonal antibody raised against a partial recombinant KCNN3.
• Formulation: 50% glycerol
• Gene: KCNN3
• Gene Accession No.: NM_170782
• Gene Alias: KCa2.3/SK3/SKCA3/hSK3
• Gene Symbols: KCNN3
• Host Species: Mouse
• Immunogen: KCNN3 (NP_740752, 301 a.a. ∼ 410 a.a) partial recombinant protein with GST tag.
• Quantity: 50 μL
• Regulatory Status: RUO
• Whole Molecule: Yes
• Primary or Secondary: Primary
• Gene ID (Entrez): 3782
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Form: Serum