KDELR2, Rabbit, Monoclonal Antibody, Abnova™

Catalog No.	Quantity
89-210-666	1 mg x up to 3 Abs

Catalog No. 89-210-666 Supplier Abnova Corporation Supplier No. H00011014K

Description

Includes

Up to three rabbit IgG clones of 1mg each will be delivered to customer.

Rabbit monoclonal antibody raised against a human KDELR2 peptide using ARM Technology.

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq

Library Construction: Nonfusion antibody library from rabbit spleen (ARM Technology)
Expression: Overexpression vector and transfection into 293H cell line

Order Info

1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.

Specifications

• Antigen: KDELR2
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Concentration: 1mg
• Conjugate: Unconjugated
• Description: KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
• Formulation: In 1X PBS, pH 7.4
• Gene: KDELR2
• Gene Accession No.: KDELR2
• Gene Alias: ELP-1, ERD2.2, FLJ45532
• Gene Symbols: KDELR2
• Host Species: Rabbit
• Immunogen: A synthetic peptide of human KDELR2
• Quantity: 1 mg x up to 3 Abs
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 11014
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG