MilliporeSigma™ anti-KLF5 (Krnppel-like factor 5), Polyclonal, ™

Supplier:  MilliporeSigma™ 071580/DEL

Catalog No. 50-172-292

Description

Kr?ppel-like factors (KLFs) zinc finger-containing transcription factors with regulatory functions in cell growth, proliferation, differentiation, and embryogenesis. KLF5, (also known as BTEB2 and IKLF), is essential for mouse embryo development. KLF5 activates many genes during cardiovascular remodeling, including PDGFa/b, Egr-1, PAI-1, iNOS, and VEGF receptors, making KLF a potential therapeutic target for cardiovascular disease. KLF5 also plays a role in angiogenesis and in development of several tumor types including breast, prostate, bladder, colon, esophagus, and skin. KLF5 is closely related to other of the KLF family members. However, KLF5 and KLF4 exhibit opposite effects on regulation of gene transcription, despite binding to similar, if not identical, cis-acting DNA sequences. In addition, KLF4 and 5 exert contrasting effects on cell proliferation in many instances; while KLF4 is an inhibitor of cell growth, KLF5 stimulates proliferation. KLF5 protein is enriched in intestinal tissue.

Chromatin Immunoprecipitation, Immunohistochemistry, Western Blotting

Specifications

• Antigen: KLF5 (Kruppel-like factor 5)
• Concentration: 1.4mg/mL
• Host Species: Rabbit
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary

• Classification: Polyclonal
• Conjugate: Unconjugated
• Immunogen: The immunogen was a KLH-conjugated synthetic peptide corresponding to amino acids 95-111 of mouse/rat KLF5.
• Quantity: 100 μL
• Research Discipline: Epigenetics
• Target Species: Human, Mouse, Rat