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MilliporeSigma™ anti-Klotho, Polyclonal

Catalog No. 42350050UG Shop All MilliporeSigma Products
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Quantity:
50 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
42-350-050UG 50 μg Unconjugated
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Catalog No. 42-350-050UG Supplier MilliporeSigma™ Supplier No. 42350050UG
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Description

Rabbit Polyclonal Antibody

Specifically detects Klotho Clone: in Mouse samples, and it is validated for ELISA, Immuno Blotting

Inactivation mutation of the recently discoveredklotho gene in mice causes a syndrome resembling aging. Homozygous mutant klotho (kl/kl) mice exhibit premature aging phenotypes such as osteoporosis, age related skin changes, ectopic calcification, atrophy of genital organs and thymus, atherosclerosis, emphysema, ataxia, and short life span. Thekl gene encodes a membrane protein whose extracellular domain carries homology toβ-glucosidases. There also exists a splice variant ofkl mRNA that encodes a putative secreted protein in both human and mouse.kl gene expression was observed to be tissue specific. Improvement of systemic aging phenotypes inkl/kl mice occurs even when the exogenous expression was limited to some organs, suggesting that KL associated aging is regulated through a humoral signaling pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Klotho
Applications ELISA, Immunoblot, Immunoblot
Classification Polyclonal
Conjugate Unconjugated
Formulation In PBS, 0.1% BSA, pH 7.5.
Host Species Rabbit
Immunogen a synthetic peptide corresponding to a 17-amino acid sequence near the C-terminus of murine Klotho
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽100kDa Klotho protein.
Target Species Mouse
Content And Storage −20°C
Form Purified
Isotype IgG
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For Research Use Only

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