Klotho Rabbit anti-Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA129899
PA1-29899 detects Klotho from mouse samples. PA1-29899 has been successfully used in Western blot and ELISA applications. PA1-29899 is expected to cross-react with human (82% identity with immunogen) due to sequence homology. The PA1-29899 immunogen is Synthetic peptide of 17 amino acids (Mouse) (C terminal). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.Animal models of human aging which display the characteristic diseases associated with aging provide insight into the cause of such diseases. Recently a trangenic mouse model, called Klotho, with several premature aging phenotypes has been described. They display premature aging phenotypes such as Osteoporosis, age related skin changes, ectopic calcifications, atrophy of gentital organs and thymus, emphysema and short life span. KL protein associated with the Klotho mutation is a 1014 amino acid long peptide. It has a putative signal sequence at its N-terminus and a single transmembrane domain near its C-terminus, which is postulated to anchor it to the membrane. KL gene expression was observed to be tissue specific. Improvement of systemic aging phenotypes in kl/kl mice occurs even when the exogenous expression was limited to some organs, suggested that KL associated aging is regulated through humoral signaling pathway. KL has been reported to be locallized on the cell surface when expressed on Cho cells. Human kl cDNA is expected to encode a protein of 1012 amino acids.
|Synthetic peptide corresponding to 17 C-terminal residues of mouse Klotho.|
|Antigen affinity chromatography|
|ELISA, Western Blot|
|0.1M tris HCl with 0.2% BSA and 0.05% sodium azide; pH 7.5|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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