Invitrogen™ Klotho Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521078

Catalog No. PIPA521078

Description

A suggested positive control is HepG2 cell lysate. PA5-21078 can be used with blocking peptide PEP-1192.

KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.

Specifications

• Antigen: Klotho
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KL
• Gene Alias: alpha-kl; HFTC3; Kl; Klotho; Klotho peptide; secreted form of Klotho protein
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16591, 83504, 9365
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: O35082, Q9UEF7, Q9Z2Y9
• Gene Symbols: KL
• Immunogen: A 17 amino acid peptide near the center of human KLOTHO.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG