Klotho Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA521078
A suggested positive control is HepG2 cell lysate. PA5-21078 can be used with blocking peptide PEP-1192.KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|16591, 83504, 9365|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|Q9UEF7, O35082, Q9Z2Y9|
|A 16 amino acid peptide near the center of human KLOTHO.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
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