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KLRG1 Hamster anti-Mouse, Brilliant Violet 605, Clone: 2F1, BD

Hamster Monoclonal Antibody

Manufacturer:  BD Biosciences 564013

Catalog No. BDB564013


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Description

Description

The 2F1 monoclonal antibody specifically binds to KLRG1 ( K iller cell L ectin-like R eceptor mmunoreceptor T yrosine-based I nhibitory M otif); its ligand has not been identified KLRG1 is expressed mainly as a homodimeric molecule consisting of two N-glycosylated subunits of approximately 30-38 kDa. The level of KLRG1 expression is reduced in MHC class I-deficient mice, although direct binding of KLRG1 to MHC class I antigens could not be detected. Cross-linking of KLRG1 by 2F1 mAb reduces TCR-mediated Ca++ mobilization and cytotoxic responses (but not IFN- γproduction) by CD8+ T cells and inhibits IFN- γand TNF- α production and redirected lysis by NK cells.

This antibody is conjugated to BD Horizon™ BV605 which is part of the BD Horizon Brilliant Violet™ family of dyes. With an Ex Max of 407-nm and Em Max of 602-nm, BD Horizon BV605 can be excited by a violet laser and detected with a standard 610/20-nm filter set. BD Horizon BV605 is a tandem fluorochrome of BD Horizon BV421 and Cy™3.5. Due to the excitation of Cy3.5 by the green (532 nm) and yellow-green (561 nm) lasers, there will be significant spillover into the PE and BD Horizon PE-CF594 detectors off the green or yellow-green lasers. BD Horizon BV605 conjugates are very bright, often exhibiting brightness equivalent to PE conjugates and can be used as a third color off of the violet laser.

Specifications

Specifications

KLRG1
2F1
Brilliant Violet 605
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Hamster
IgG2, κ
RUO
Primary
Murine
Flow Cytometry
0.2mg/mL
Klrg1; Killer cell lectin-like receptor subfamily G member 1; MAFA
Affinity Purified
A-LAK from C57BL/6 mice
50μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
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