KRIT1, Mouse, Clone: 2C7, Abnova™

Catalog No.	Quantity
89-016-471	100 μg

Catalog No. 89-016-471 Supplier Abnova Corporation Supplier No. H00000889M01

Description

Mouse monoclonal antibody raised against a partial recombinant KRIT1.

This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq

Sequence: AAFFTGQIFTKASPSNHKVIPVYVGVNIKGLHLLNMETKALLISLKYGCFMWQLGDTDTCFQIHSMENKMSFIVHTKQAGLVVKLLMKLNGQLMPTERNS

Specifications

• Antigen: KRIT1
• Applications: ELISA
• Classification: Monoclonal
• Clone: 2C7
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against a partial recombinant KRIT1.
• Formulation: PBS with no preservative; pH 7.4
• Gene: KRIT1
• Gene Accession No.: NM_004912
• Gene Alias: CAM/CCM1
• Gene Symbols: KRIT1
• Host Species: Mouse
• Immunogen: KRIT1 (NP_004903, 637 a.a. ∼ 736 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Purification Method: Affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 889
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a λ