KV1.2 (KCNA2) Rabbit anti-Bovine, Canine, Human, Mouse, Porcine, Rat, Xenopus laevis, Zebrafish, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523005

Catalog No. PIPA523005

Description

Suggested positive control: HEK293 cell lysate.

Kcna2 is a voltage-gated potassium channel (KV) that belongs to the 6-TM family of potassium channel and also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. The diverse functions of potassium channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). The Kcna2 gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. Kcna2 contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. Further, Kcna2 belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of the Kcna2 gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. Diseases associated with KCNA2 include Epileptic Encephalopathy (Early Infantile, 32) and Undetermined Early-Onset Epileptic Encephalopathy.

Specifications

• Antigen: KV1.2 (KCNA2)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KCNA2
• Format: Liquid
• Gene Symbols: KCNA2, kcna2.S, LOC100537815
• Immunogen: Synthetic peptide made to rat Kv1.2 (within residues 50-100), which is identical in all members of the Kv1 family.
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Bovine, Canine, Human, Mouse, Porcine, Rat, Xenopus laevis, Zebrafish

• Applications: Immunoprecipitation, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: Q28293, P16389, P63141, P63142
• Gene Alias: RP11-284N8.1, HBK5, HK4, HUKIV, KV1.2, MK2, NGK1, RBK2, potassium voltage-gated channel subfamily A member 2, voltage-gated K(+) channel HuKIV, voltage-gated potassium channel HBK5, voltage-gated potassium channel protein Kv1.2, voltage-gated potassium channel subunit Kv1.2
• Host Species: Rabbit
• Isotype: IgG
• Quantity: 100 μL
• Storage Requirements: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Primary or Secondary: Primary
• Gene ID (Entrez): 100537815, 16490, 25468, 3737, 373840, 397292, 404022, 539608