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LAP Mouse anti-Human, PerCP-Cy5.5, Clone: TW4-2F8, BD

Catalog No. BDB562544 Shop All BD Biosciences Products
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BDB562544 50 Tests
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Catalog No. BDB562544 Supplier BD Biosciences Supplier No. 562544
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Description

Mouse Monoclonal Antibody

The TW4-2F8 monoclonal antibody specifically binds to Latency-Associated Peptide (LAP), a component of the dimeric Transforming Growth Factor-beta 1 (TGF-β1) propeptide encoded by TGFB1. Prior to secretion, the dimeric LAP-TGF-β1 propeptide is cleaved resulting in a biologically inactive form of dimeric TGF-β1 that is noncovalently associated with dimeric LAP (latent TGF-β1). This complex may be expressed on the surface of TGF-β1TGF-β1. TGF-β1 is a potent multifunctional cytokine that regulates numerous processes including development, hematopoiesis, tissue remodeling, wound repair, and immunity as well as cancer and autoimmune diseases. Clone TW4-2F8 is routinely quality tested through intracellular staining of LAP in P3UI-TGFβ1 transfected cells.

TRUSTED_SUSTAINABILITY

Specifications

Antigen LAP
Applications Flow Cytometry
Classification Monoclonal
Clone TW4-2F8
Conjugate PerCP-Cyanine5.5
Description Latency-associated peptide; TGFB1; TGFbeta; Transforming growth factor beta
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human TGF-β1
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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