LBP Mouse anti-Human, Clone: 1C7, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA140130
MA1-40130 detects LBP from human samples. MA1-40130 has been successfully used in ELISA,functional assays and immunoprecipitation applications. ELISA: monoclonal antibody 1C7 can be used both as coating and as detector. The MA1-40130 immunogen is the LPS binding site on LBP. Endotoxin <24 EU/mg.LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. LBP strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000-fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.
|PBS with 0.1% BSA and no preservative|
|lipopolysaccharide binding protein|
|ELISA, Functional Assay, Immunoprecipitation|
|LPS binding site on LBP.|
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