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MilliporeSigma™ anti-LBPA Clone: 6C4,

Catalog No. MABT837MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABT837MI 100 μg Unconjugated
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Catalog No. MABT837MI Supplier MilliporeSigma™ Supplier No. MABT837
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Description

Mouse Monoclonal Antibody

Specifically detects LBPA Clone: 6C4 in All samples, and it is validated for Dot Blot, Electron Microscopy, ELISA, Immunocytochemistry

Lyso bis-phosphatidic acid (LBPA, Lysobisphosphatidic acid, L(bis)PA) is a lipid that is exclusively located in late endosomes and is used as a late endosome marker. One of the characteristic features of late endosomes is a complex system of internal membranes within the lumen that contains large amounts of the unique, poorly degradable LBPA, and thus forms a specialized membrane domain within endosomes. Late endosomes function not only as a major protein-sorting compartment, but also an obligatory station for LDL and other endocytosed ligands destined for degradation. Research shows that the LBPA-rich membranes within late endosomes regulate cholesterol transport, presumably by acting as a collection and distribution device. The genetic disease Niemann-Pick type C (NPC) is characterized by both lysosomal and endosomal storage disorders. In skin fibroblasts from NPC patients, cholesterol accumulation is seen within vesicles containing late endosome markers LBPA and Rab7.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LBPA
Applications Dot Blot, Immunoassay, ELISA, Immunocytochemistry
Classification Monoclonal
Clone 6C4
Conjugate Unconjugated
Formulation Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Host Species Mouse
Immunogen Endosomal membranes from baby hamster kidney fibroblasts (BHK) corresponding to Hamster LBPA.
Purification Method Protein G purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Cell Structure
Primary or Secondary Primary
Test Specificity Clone 6C4 specifically detects LBPA, but not PC, PE, SM, PS, CL, PI, Sul, Chol, Cer, or CE purified from baby hamster kidney (BHK) cell lipid extract (Kobayahsi, T., et al. (1998). Nature. 392(6672):193-197).
Target Species All species
Content And Storage 2°C to 8°C for one year from date of shipment
Form Purified
Isotype IgG1 κ
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For Research Use Only

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