Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

LEF1 Mouse anti-Human, Clone: 1C3.1D10, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112488

Catalog No. 01-674-336


Add to cart

Description

Description

This antibody does not cross-react with TCF-1 or TCF-4.

Lymphoid Enhancer Factor-1 (LEF-1) is an HMG 1/2-like DNA binding/bending protein and is a member of the LEF/TCF transcription factor family. There are four LEF/TCF family members in mammalian systems (LEF-1, TCF-1, TCF-3 and TCF -4), and orthologs to these factors have been identified in many different species. LEF/TCFs are downstream mediators of Wnt/ Wingless signals. Wnt signaling drives cell polarity, cell fate and cell growth decisions in embryonic tissues and in post-natal tissues that continue to develop from mitotically active stem cell precursors. Misregulation of Wnt signaling is also implicated as a root cause of many different cancers, such as colon cancer, melanoma, breast cancer, prostate cancer and others. This antibody recognizes an epitope in amino acids 256-308 of LEF-1. This region is between the transactivation domain and the HMG binding domain of LEF-1 and is conserved in all LEF-1 isoforms.
Specifications

Specifications

LEF1
Monoclonal
Unconjugated
LEF1
Liquid
LEF1
Recombit full length LEF-1 protein.
Protein A/G
RUO
Antibody
Monoclonal
Human
Western Blot
1C3.1D10
PBS with 0.08% sodium azide
Q9UJU2
b-catenin binding domain
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
51176
Documents
Promotions

Promotions

Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit