LEF1 Mouse anti-Human, Clone: 1C3.1D10, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA112488
This antibody does not cross-react with TCF-1 or TCF-4.Lymphoid Enhancer Factor-1 (LEF-1) is an HMG 1/2-like DNA binding/bending protein and is a member of the LEF/TCF transcription factor family. There are four LEF/TCF family members in mammalian systems (LEF-1, TCF-1, TCF-3 and TCF -4), and orthologs to these factors have been identified in many different species. LEF/TCFs are downstream mediators of Wnt/ Wingless signals. Wnt signaling drives cell polarity, cell fate and cell growth decisions in embryonic tissues and in post-natal tissues that continue to develop from mitotically active stem cell precursors. Misregulation of Wnt signaling is also implicated as a root cause of many different cancers, such as colon cancer, melanoma, breast cancer, prostate cancer and others. This antibody recognizes an epitope in amino acids 256-308 of LEF-1. This region is between the transactivation domain and the HMG binding domain of LEF-1 and is conserved in all LEF-1 isoforms.
|Recombit full length LEF-1 protein.|
|PBS with 0.08% sodium azide|
|b-catenin binding domain|
|-20° C, Avoid Freeze/Thaw Cycles|
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