MilliporeSigma™ anti-LHX2, Polyclonal

Catalog No.	Quantity	Conjugate
ABE1402MI	100 μL	Unconjugated

Catalog No. ABE1402MI Supplier MilliporeSigma™ Supplier No. ABE1402

Description

Rabbit Polyclonal Antibody

Specifically detects LHX2 Clone: in Human, Mouse samples, and it is validated for ChIP-seq, Chromatin Immunoprecipitation, Immunofluorescence, Western Blotting

LIM/homeobox protein Lhx2 (UniProt Q9Z0S2; also known as Homeobox protein LH-2, LIM homeo box protein 2, Lim2) is encoded by the Lhx2 gene (Gene ID 16870) in murine species. Lhx2 is a transcription factor that plays an important role in controlling the behavior of progenitor cells involved in the development of the skin hair cycling, eye, forebrain, limb, hematopoietic, olfactory, and pituitary systems. Lhx2 is shown to regulate a significant number of hair follicle stem cell (HF-SC) signature genes, as well as cytoskeletal and adhesion molecules within the niche where HF-SCs reside as a single layer of polarized, quiescent epithelial cells. Lhx2 deficiency leads to baldness, because the niche can no longer anchor its hair and maintain the proper behavior of its SCs as a result of greatly perturbed HF-SCs polarization and niche architecture.

Specifications

• Antigen: LHX2
• Applications: ChIP Assay, ChIP sequencing (ChIP-seq), Immunofluorescence, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: Rabbit polyclonal serum with 0.05% sodium azide.
• Gene Accession No.: Q9Z0S2
• Gene Symbols: Lhx2
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to mouse LHX2.
• Purification Method: Unpurified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Epigenetics, Nuclear Function
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_034840
• Target Species: Human, Mouse
• Content And Storage: −20°C for one year
• Form: Serum

For Research Use Only