MilliporeSigma™ anti-LHX2, Polyclonal

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ ABE1402

Catalog No. ABE1402MI

Description

Specifically detects LHX2 Clone: in Human, Mouse samples, and it is validated for ChIP-seq, Chromatin Immunoprecipitation, Immunofluorescence, Western Blotting

LIM/homeobox protein Lhx2 (UniProt Q9Z0S2; also known as Homeobox protein LH-2, LIM homeo box protein 2, Lim2) is encoded by the Lhx2 gene (Gene ID 16870) in murine species. Lhx2 is a transcription factor that plays an important role in controlling the behavior of progenitor cells involved in the development of the skin hair cycling, eye, forebrain, limb, hematopoietic, olfactory, and pituitary systems. Lhx2 is shown to regulate a significant number of hair follicle stem cell (HF-SC) signature genes, as well as cytoskeletal and adhesion molecules within the niche where HF-SCs reside as a single layer of polarized, quiescent epithelial cells. Lhx2 deficiency leads to baldness, because the niche can no longer anchor its hair and maintain the proper behavior of its SCs as a result of greatly perturbed HF-SCs polarization and niche architecture.

Specifications

• Antigen: LHX2
• Classification: Polyclonal
• Formulation: Rabbit polyclonal serum with 0.05% sodium azide.
• Gene Symbols: Lhx2
• Immunogen: Recombinant protein corresponding to mouse LHX2.
• Quantity: 100 μL
• Research Discipline: Epigenetics, Nuclear Function
• Gene ID (Entrez): NP_034840
• Content And Storage: −20°C for one year

• Applications: ChIP Assay, ChIP sequencing (ChIP-seq), Immunofluorescence, Western Blot
• Conjugate: Unconjugated
• Gene Accession No.: Q9Z0S2
• Host Species: Rabbit
• Purification Method: Unpurified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Form: Serum

For Research Use Only