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Delta-Like Protein 1 Rat anti-Mouse, PE, Clone: 30B11.1, BD

Catalog No. BDB563684 Shop All BD Biosciences Products
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BDB563684 50 μg
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Catalog No. BDB563684 Supplier BD Biosciences Supplier No. 563684

Description

Rat Monoclonal Antibody

The 30B11.1 monoclonal antibody specifically binds to Delta-like1 (Dll1) which is also known as Delta1 and DL1. Dll1 is a 90-100 kDa type 1 transmembrane protein. It is a member of the Delta/Serrate/Jagged Family of Notch ligands. Notch ligands are classified by the presence of specific structural motifs including an N-terminal Delta-Serrate-LAG-2 (DSL) domain, EGF repeats, and the DOS domain (a specialized EGF repeat). The Notch family of transmembrane receptors and their ligands control cell-fate “decisions” during the development of many organs in a wide variety of animal species. Dll1 is expressed in the paraxial mesoderm and in some cells in the nervous system in early development. In the adult, Dll1 is expressed in a variety of tissues including at high levels in the heart and at various levels by cells within lymphoid tissues. Although Dll1 does not normally appear to play a role in T cell development, Dll1 and Notch interactions are essential for marginal zone B cell development and reportedly promote the differentiation of antibody producing cells.

TRUSTED_SUSTAINABILITY

Specifications

Antigen Delta-Like Protein 1
Applications Flow Cytometry
Classification Monoclonal
Clone 30B11.1
Concentration 0.2mg/mL
Conjugate PE
Description Delta like-1; Delta-like 1; Delta1; Dll1; DL1; DL-1
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse DL1 Extracellular Domain
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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