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LIMK1 Mouse, Unlabeled, Clone: 42, BD

Mouse Monoclonal Antibody

$225.00 - $415.00

Specifications

Antigen LIMK1
Isotype IgG1
Immunogen Human LIMK1 aa. 232-333
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611748
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BD Biosciences
611748
50μg Each for $225.00
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BDB611749
View Documents
BD Biosciences
611749
150μg Each for $415.00
Add to cart
 
Description

Description

Two LIM motif-containing protein kinases (LIMK) have been identified, LIMK1 and LIMK2. These kinases contain two N-terminal LIM domains, a central PDZ domain, and a C-terminal Ser/Thr kinase domain. LIMK1 is highly expressed in brain, heart, and skeletal muscle, while LIMK2 exhibits the highest expression in placenta, liver, lung, kidney, and pancreas. LIMK1 is localized to the actin cytoskeleton and phosphorylates the actin binding/depolymerizing factor, cofilin. During Rho-induced neurite retraction, activation of ROCK leads to LIMK1 activation via phosphorylation at Thr508. In COS-7 cells, disruption of the second LIM domain or the PDZ domain increases LIMK1-induced aggregation of the actin cytoskeleton. In addition, a 32kDa splice variant that contains only the N-terminus (dLIMK1) suppresses LIMK1 activity by interaction with the C- terminal kinase domain. In humans, deletion of LIMK1 has been implicated in Williams syndrome, a disorder that produces a distinct cognitive profile and vascular disease. Thus, LIMK1, and its splice variant dLIMK1, are thought to have important roles in the regulation of the actin cytoskeleton in a wide varitey of tissues.

Host Species: Mouse
Clone: 42
Isotype: IgG1
Species Reactivity [for Features Main]: Rat
Immunogen: Human LIMK1 aa. 232-333

Immunofluorescence, Western Blotting

Specifications

Specifications

LIMK1
Human LIMK1 aa. 232-333
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
42
250μg/mL

For Research Use Only.

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