Lin-28 Mouse anti-Human, PE, Clone: 6D1F9, BD

Catalog No.	Quantity
BDB563398	50 Tests

Catalog No. BDB563398 Supplier BD Biosciences Supplier No. 563398

Description

Mouse Monoclonal Antibody

Lin-28 is an evolutionarily conserved RNA-binding protein that is expressed in embryonic tissue, embryonic stem cells, and some adult tissues (e.g. cardiac and skeletal muscle). Within these cells, it is localized to ribosomes, P-bodies, and stress granules. During embryonic development, Lin-28 acts as a “translational enhancer” by binding to certain mRNAs and increasing their translation efficiency. Additionally, Lin-28 is overexpressed in some human cancer cell lines and is associated with the malignant transformation of cells as well as advanced human malignancies. This role is thought to be tied to the binding of Lin-28 to pre-microRNA of let-7, which in its mature form promotes terminal differentiation of stem cells and suppresses tumors. The binding of Lin-28 to the immature version of let-7 blocks its cleavage into mature microRNA, thereby preventing it from carrying out its function in tumor suppression. Lin-28, in combination with additional factors, has been used to reprogram human somatic cells into induced pluripotent stem cells.

Specifications

• Antigen: Lin-28
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: 6D1F9
• Conjugate: PE
• Description: Lin-28A, LIN28A, CSDD1, LIN28, ZCCHC1
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Host Species: Mouse
• Immunogen: Human Lin-28 Recombinant Protein
• Purification Method: Affinity Purified
• Quantity: 50 Tests
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
• Isotype: IgG1 κ