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LITAF Mouse anti-Human, Unlabeled, Clone: 30, BD

Catalog No. BDB611614 Shop All BD Biosciences Products
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BDB611614 50 μg
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Catalog No. BDB611614 Supplier BD Biosciences Supplier No. 611614

Description

Mouse Monoclonal Antibody

TNFα (Tumor Necrosis Factor α) is a pleiotropic cytokine that conveys either beneficial (prevention of cancers and infection, activation of inflammatory responses) or detrimental (mediation of septic shock, inflammation, and apoptosis) effects to the host. It is produced and secreted primarily by monocytes and macrophages in response to stimulation with lipopolysaccharide (LPS), a principle endotoxic component. LPS-induced TNFα factor (LITAF) is a nuclear factor that was purified as a result of its ability to bind to a DNA fragment from the TNFα promoter region. LITAF expression is dependent on LPS induction and PMA differentiation in THP-1 cells and is observed at high levels in spleen, lymph node, and peripheral blood leukocytes. Antisense inhibition of LITAF causes a reduction in TNFα expression in THP-1 cells. In addition, p53 induces the expression of a transcript called PIG7, which has 98% homology with LITAF. Thus, LITAF is thought to link p53 pathways with the induction of TNFα gene expression in response to LPS stimulation and to function, possibly as a transcription factor, to regulate the expression of this highly potent cytokine. This antibody was generated to the LITAF aa 1-212 sequence (Genbank accession no. U77396). Recent reports indicate that the nucleotide coding sequence for LITAF may differ and instead, encode for a protein designated as SIMPLE. Under the sequence for SIMPLE, the LITAF aa 1-212 sequence used to generate this antibody corresponds to the aa 1-126 region of SIMPLE.

Host Species: Mouse
Clone: 30
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human LITAF aa. 1-212

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen LITAF
Applications Western Blot
Classification Monoclonal
Clone 30
Concentration 250μg/mL
Conjugate Unconjugated
Description LPS Induced TNFα Factor
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human LITAF aa. 1-212
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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