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Ly-51 Mouse anti-Mouse, PE, Clone: BP-1, BD

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BDB553735 0.2 mg
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Catalog No. BDB553735 Supplier BD Biosciences Supplier No. 553735
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Description

Mouse Monoclonal Antibody

The BP-1 antibody reacts with an epitope of the 6C3/BP-1 (Ly-51) glycoprotein cell-surface differentiation antigen, which was originally identified on pre-B cell lymphomas (spontaneous and chemical- or retrovirus- transformed, in vitro and in vivo). 6C3/BP-1 is a homodimer cell-surface glycoprotein with 140kDa subunits which has been identified to possess aminopeptidase A (APA) activity. The same antigen is expressed at high levels on bone marrow stromal cell lines which support in vitro B lymphopoieses, on thymic dendritic cells and cortical epithelial cells, and on a wide variety of mouse and rat tissues known to possess APA activity. Subsets of normal bone marrow pre-B and B lymphocytes express low levels of Ly-51, which is rapidly up-regulated on the pre-B cells in the presence of IL-7. A role for the 6C3/BP-1 molecule in the IL-7-driven proliferation of B cell precursors has been postulated. However, B-cell abnormalities were not detected in Ly-51-deficient mice. Mature B lymphocytes, thymocytes, peripheral T lymphocytes, erythroid cells, and myeloid cells (with the exception of thymic dendritic cells) do not express Ly-51.

Host Species: Mouse
Clone: BP-1
Isotype: IgG2a κ
Species Reactivity: Mouse
Immunogen: Abelson murine leukemia virus-transformed BALB/c mouse pre-B cell line 18.81

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen Ly-51
Applications Flow Cytometry
Classification Monoclonal
Clone BP-1
Concentration 0.2mg/mL
Conjugate PE
Description 6C3/BP-1 Antigen
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Abelson murine leukemia virus-transformed BALB/c mouse pre-B cell line 18.81
Purification Method Affinity Purified
Quantity 0.2 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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For Research Use Only.

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