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MAD2 Mouse, Unlabeled, Clone: 48, BD

Mouse Monoclonal Antibody

$225.00 - $445.00

Specifications

Antigen MAD2
Isotype IgG2a
Immunogen Aqueous buffered solution containing BSA
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610679
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BD Biosciences
610679
150μg
Each for $445.00
Add to cart
 
BDB610678
View Documents
BD Biosciences
610678
50μg
Each for $225.00
Add to cart
 
Description

Description

Progression of the mammalian cell cycle is regulated by phosphorylation/dephosphorylation and synthesis/degradation of many key proteins. These events are of utmost importance at the checkpoints, or transition points, of the cell cycle. MAD2 (Mitotic Arrest Deficient) is the human homolog of a yeast and Xenopus protein that is essential for spindle assembly during mitosis. The human hsMAD2 gene encodes a protein of 205 amino acids with a predicted molecular weight of 23.5 kDa. Binding of affinity purified polyclonal antibodies to the MAD2 protein prevents mitosis of HeLa cells. This indicates that, like its invertebrate relatives, MAD2 is necessary for mitosis. Furthermore, MAD2 is localized at the kinetochore of condensed chromosomes during mitosis and cells defective in the mitotic checkpoint have reduced levels of MAD2.

Specifications

Specifications

MAD2
Aqueous buffered solution containing BSA
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Mitotic Arrest Deficient-2
IgG2a
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
48
250μg/mL
Store undiluted at -20°C.
SDS

For Research Use Only.

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