MilliporeSigma™ anti-Mannose 6-Phosphate Receptor Clone: 2G11,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ 444105100UG

Catalog No. 44-410-5100UG

Description

Specifically detects Mannose 6-Phosphate Receptor Clone: 2G11 in Bovine, Human, Monkey samples, and it is validated for Immunofluorescence, Immunohistochemistry, Immunoprecipitation

Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are moved about in the cell by two distinct but interconnected cycles by means of ∽300kDa cation-independent MPRs. The biosynthetic cycle refers to the MPR transport of newly synthesized lysosomal enzymes from the trans Golgi network to late endosomes or early lysosomes. The endocytic cycle transports extracellular lysosomal enzymes from the plasma membrane via clathrin-coated vesicles to early endosomes. The entire pool of MPRs cycles between these cellular compartments every 3 hours. The steady state distribution of MPRs is predominantly late endosomes, fewer in the trans Golgi network, and ∽10% at cell surface. In addition to its man6P binding activity, MPR contains a separate binding site for the type II insulin-like growth factor and is capable of binding both man6P and IGF-II simultaneously. An ∽240kDa soluble, truncated form of the extracellular domain of MPR has been detected circulating in serum that is capable of binding both ligands.

Specifications

• Antigen: Mannose 6-Phosphate Receptor
• Classification: Monoclonal
• Conjugate: Unconjugated
• Host Species: Mouse
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Bovine, Human, Monkey
• Form: Purified

• Applications: Immunofluorescence, Immunohistochemistry, Immunoprecipitation
• Clone: 2G11
• Formulation: In PBS.
• Immunogen: native bovine cation independent (CI)-mannose 6-phosphate receptor
• Regulatory Status: RUO
• Test Specificity: Recognizes the ∽300kDa mannose 6-phosphate receptor protein.
• Content And Storage: −20°C
• Isotype: IgG2a

For Research Use Only