MAP3K8, Rabbit, Monoclonal Antibody, Abnova™

Rabbit monoclonal antibody raised against a human MAP3K8 peptide using ARM Technology.

Supplier:  Abnova Corporation H00001326K

Catalog No. 89-205-465

Includes: Up to three rabbit IgG clones of 1mg each will be delivered to customer.

Description

This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. [provided by RefSeq

Library Construction: Nonfusion antibody library from rabbit spleen (ARM Technology)
Expression: Overexpression vector and transfection into 293H cell line

Order Info

1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.

Specifications

• Antigen: MAP3K8
• Classification: Monoclonal
• Conjugate: Unconjugated
• Formulation: In 1X PBS, pH 7.4
• Gene Accession No.: MAP3K8
• Gene Symbols: MAP3K8
• Immunogen: A synthetic peptide of human MAP3K8
• Regulatory Status: RUO
• Gene ID (Entrez): 1326
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG

• Applications: ELISA, Western Blot
• Concentration: 1mg
• Description: mitogen-activated protein kinase kinase kinase 8
• Gene: MAP3K8
• Gene Alias: COT, EST, ESTF, FLJ10486, TPL2, Tpl-2, c-COT
• Host Species: Rabbit
• Quantity: 1 mg x up to 3 Abs
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid