anti-MAPK8, MaxPab™ Polyclonal, Abnova

Mouse Polyclonal

Manufacturer: Abnova Corporation H00005599B01P

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Catalog No. 89-018-888

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    Antigen mitogen-activated protein kinase 8
    Conjugate Unlabeled
    Cross Reactivity Human,Rat
    Format Affinity Purified
    Host Species Mouse
    Immunogen MAPK8 (NP_620637.1, 1 a.a. ∽427 a.a) full-length human protein.
    Purification Method Protein A column
    Quantity 50μg
    Regulatory Status RUO
    Research Discipline Kinases
    Primary or Secondary Primary
    Monoclonal or Polyclonal Polyclonal

    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

    Host Species: Mouse
    Species Reactivity [for Features Main]: Human, Rat
    Immunogen: MAPK8 (NP_620637.1, 1aa ~ 427aa) full-length human protein

    Detection Antibody, Immunofluorescence, Western Blotting

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