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MARCH8, clone: 710424, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524329

Catalog No. PIMA524329

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

MARCH8 (c-MIR) is a novel E3 ubiquitin ligase designated as the modulator of immune recognition (MIR) family, whose catalytic domain is a variant RING domain (RING-CH domain). MARCH8 was found as a functional and structural homolog of KSHV MIR1 and MIR2. MARCH8 targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface expression through ubiquitination of its cytoplasmic tail. Furthermore, MARCH8 has been shown to down-regulate the expression of transferrin receptor and Fas, an important molecule for the induction of apoptosis. MARCH8 is the first example of an E3 ubiquitin ligase that is capable of inhibiting MHC II expression. Recent findings suggest that MARCH8 may regulate immune responses by promoting ubiquitination of MHC-II and CD86, leading to their subsequent endocytosis and lysosomal degradation.

Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.
Specifications

Specifications

MARCH8
Monoclonal
0.5mg/mL
PBS with 5% trehalose and no preservative
Q5T0T0, Q9DBD2
RP11-67C2.1, MARCH-VIII, MIR, RNF178, c-MIR, E3 ubiquitin-protein ligase MARCH8, RING finger protein 178, c-mir, cellular modulator of immune recognition, cellular modulator of immune recognition (c-MIR), membrane-associated RING finger protein 8, membrane-associated RING-CH protein VIII
Murine
IgG2b
100μg
Store at-20°C, Avoid Freeze/Thaw Cycles
Primary
220972, 312656, 71779
Immunocytochemistry, Immunofluorescence, Western Blot
710424
Unconjugated
MARCH8
Lyophilized
MARCH8
E. coli-derived recombinant human MARCH8 Gln218-Val291
Protein A/G
RUO
Antibody
Monoclonal
Human, Murine, Rat
Documents
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