MASH1 Mouse, Unlabeled, Clone: 24B7.2D11, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 556604

Catalog No. BDB556604

Description

MASH1 and MASH2 (Mammalian achaete-schute Homolog 1 and 2) are basic helixloop-helix transcription factors which are mammalian homologs of the achaete-schute gene family that is required for neuronal development in Drosophila. The bHLH motif is present in many types of transcription factors including E2-2, E47, MyoD and others. MASH1 has been shown to heterodimerize with other bHLH containing transcription factors. MASH1-E12 heteromers bind to and promote transcriptional activation of muscle creatine kinase, a known target for MyoD activation. However, MASH1 appears to play its primary role during early development of the autonomic nervous system. In committed neuronal precursor cells, early expression of MASH1 activates a subset of neuron-specific genes to promote differentiation. Thus null mutations in the MASH1 gene suggest that MASH1 is a valuable marker for investigation of neural development in mammals. MASH1 is observed as an ∽34kDa protein by SDS-PAGE.

Host Species: Mouse
Clone: 24B72D11.1
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Rat MASH1 full length recombinant protein

Western Blotting

Specifications

• Antigen: MASH1
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Rat MASH1 full length recombinant protein
• Quantity: 0.1 mg
• Research Discipline: Cell Biology
• Target Species: Mouse, Rat
• Isotype: IgG1

• Applications: Western Blot
• Clone: 24B7.2D11
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

For Research Use Only.