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MASH1 Mouse, Unlabeled, Clone: 24B7.2D11, BD

Catalog No. BDB556604 Shop All BD Biosciences Products
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BDB556604 0.1 mg
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Description

Mouse Monoclonal Antibody

MASH1 and MASH2 (Mammalian achaete-schute Homolog 1 and 2) are basic helixloop-helix transcription factors which are mammalian homologs of the achaete-schute gene family that is required for neuronal development in Drosophila. The bHLH motif is present in many types of transcription factors including E2-2, E47, MyoD and others. MASH1 has been shown to heterodimerize with other bHLH containing transcription factors. MASH1-E12 heteromers bind to and promote transcriptional activation of muscle creatine kinase, a known target for MyoD activation. However, MASH1 appears to play its primary role during early development of the autonomic nervous system. In committed neuronal precursor cells, early expression of MASH1 activates a subset of neuron-specific genes to promote differentiation. Thus null mutations in the MASH1 gene suggest that MASH1 is a valuable marker for investigation of neural development in mammals. MASH1 is observed as an ∽34kDa protein by SDS-PAGE.

Host Species: Mouse
Clone: 24B72D11.1
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Rat MASH1 full length recombinant protein

Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen MASH1
Applications Western Blot
Classification Monoclonal
Clone 24B7.2D11
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Rat MASH1 full length recombinant protein
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Mouse, Rat
Content And Storage Store undiluted at 4°C
Isotype IgG1
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For Research Use Only.

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