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MilliporeSigma™ anti-Matriptase/MT-SP1, Polyclonal
Rabbit Polyclonal Antibody
Supplier: MilliporeSigma™ IM101450UG
Description
Specifically detects Matriptase/MT-SP1 Clone: in Human samples, and it is validated for Immunoprecipitation
Matriptase (MT-SP1, ACC. No. NP_068813), a type II membrane serine protease, may play important roles in cell migration and tumor cell metastasis. It is a mosaic protein with broad spectrum cleavage activity and two potential regulatory modules. Matriptase can convert hepatocyte growth factor/scatter factor to its active form, which can then activate c-Met tyrosine phosphorylation. Furthermore, protease-activated receptor 2 (PAR2) and enzymatically inactive single-chain uPA (pro-uPA) were identified as substrates of matriptase. Matriptase may regulate PAR2 mediated functions such as inflammatory responses, cell adhesion, and uPA-dependent tumor cell invasion and metastasis. The expression of matriptase is associated with a more invasive phenotype.
Specifications
Matriptase/MT-SP1 | |
Polyclonal | |
In Tris-citrate/phosphate buffer, pH 7.0-8.0. | |
a synthetic peptide corresponding to amino acids near the C-terminus of human matriptase | |
RUO | |
Recognizes the ∽75kDa matriptase protein in MCF-7 cells. | |
2°C to 8°C | |
IgG |
Immunoprecipitation | |
Unconjugated | |
Rabbit | |
50 μg | |
Primary | |
Human | |
Purified |
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Product Title
For Research Use Only
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