MilliporeSigma™ anti-Matriptase/MT-SP1, Polyclonal

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ IM101450UG

Catalog No. IM101450UG

Description

Specifically detects Matriptase/MT-SP1 Clone: in Human samples, and it is validated for Immunoprecipitation

Matriptase (MT-SP1, ACC. No. NP_068813), a type II membrane serine protease, may play important roles in cell migration and tumor cell metastasis. It is a mosaic protein with broad spectrum cleavage activity and two potential regulatory modules. Matriptase can convert hepatocyte growth factor/scatter factor to its active form, which can then activate c-Met tyrosine phosphorylation. Furthermore, protease-activated receptor 2 (PAR2) and enzymatically inactive single-chain uPA (pro-uPA) were identified as substrates of matriptase. Matriptase may regulate PAR2 mediated functions such as inflammatory responses, cell adhesion, and uPA-dependent tumor cell invasion and metastasis. The expression of matriptase is associated with a more invasive phenotype.

Specifications

• Antigen: Matriptase/MT-SP1
• Classification: Polyclonal
• Formulation: In Tris-citrate/phosphate buffer, pH 7.0-8.0.
• Immunogen: a synthetic peptide corresponding to amino acids near the C-terminus of human matriptase
• Regulatory Status: RUO
• Test Specificity: Recognizes the ∽75kDa matriptase protein in MCF-7 cells.
• Content And Storage: 2°C to 8°C
• Isotype: IgG

• Applications: Immunoprecipitation
• Conjugate: Unconjugated
• Host Species: Rabbit
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Purified

For Research Use Only