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MilliporeSigma™ anti-Matriptase/MT-SP1, Polyclonal

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ IM101450UG

Catalog No. IM101450UG


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Description

Description

Specifically detects Matriptase/MT-SP1 Clone: in Human samples, and it is validated for Immunoprecipitation

Matriptase (MT-SP1, ACC. No. NP_068813), a type II membrane serine protease, may play important roles in cell migration and tumor cell metastasis. It is a mosaic protein with broad spectrum cleavage activity and two potential regulatory modules. Matriptase can convert hepatocyte growth factor/scatter factor to its active form, which can then activate c-Met tyrosine phosphorylation. Furthermore, protease-activated receptor 2 (PAR2) and enzymatically inactive single-chain uPA (pro-uPA) were identified as substrates of matriptase. Matriptase may regulate PAR2 mediated functions such as inflammatory responses, cell adhesion, and uPA-dependent tumor cell invasion and metastasis. The expression of matriptase is associated with a more invasive phenotype.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Matriptase/MT-SP1
Polyclonal
In Tris-citrate/phosphate buffer, pH 7.0-8.0.
a synthetic peptide corresponding to amino acids near the C-terminus of human matriptase
RUO
Recognizes the ∽75kDa matriptase protein in MCF-7 cells.
2°C to 8°C
IgG
Immunoprecipitation
Unconjugated
Rabbit
50 μg
Primary
Human
Purified
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