methyl-CpG binding domain protein 3, Mouse, Polyclonal Antibody, Abnova
Mouse polyclonal antibody raised against a partial recombinant MBD3.
Manufacturer: Abnova Corporation H00053615A01
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex. [provided by RefSeqSequence: LMSKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHPSNKVKSDPQKAVDQPRQLFWEKKLSGLNAFDIAEELVKTMDLPKGLQGVGPGCTDETLLS
|methyl-CpG binding domain protein 3|
|MBD3 (NP_003917, 70 a.a. ~ 179 a.a) partial recombinant protein with GST tag.|
|ELISA, Western Blot|
|Mouse polyclonal antibody raised against a partial recombinant MBD3.|
|Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
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