MilliporeSigma™ anti-MCAM (MUC18; CD146), Clone: P1H12, ™ (Chemicon™)

Supplier:  MilliporeSigma™ MAB16985B/DEL

Catalog No. 50-174-928

Description

MUC18 antigen (CD146), a member of the immuoglobulin superfamily, is an intrinsic membrane glycoprotein of 110-120 kDa found on the surface of endothelial cells, bone marrow fibroblasts and various melanomas. MUC18 has been used as a marker of tumor progression in human melanoma because expression in those tumors correlates strongly with poor prognosis and the development of metastic disease. In addition, a number of human T, B and myeloid leukemic cell lines seem to express MUC18. The close structural relationship with N-CAM and related molecules suggests that MUC18 may be also a developmentally regulated cell adhesion molecule (Melanoma adhesion molecule or MCAM).

ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

• Antigen: MCAM (MUC18; CD146)
• Conjugate: Biotin
• Immunogen: Immunization of mice with HUVEC
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Semi-purified

• Classification: Monoclonal
• Host Species: Mouse
• Quantity: 100 μg
• Research Discipline: Cell Structure
• Target Species: Canine, Human, Mouse, Rabbit
• Isotype: IgG1