anti-MCAM (MUC18; CD146), Clone: P1H12, Millipore™ (Chemicon™)

Manufacturer: EMD Millipore MAB16985B/DEL

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Catalog No. 50-174-928


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    Antigen MCAM (MUC18; CD146)
    Conjugate Biotin
    Cross Reactivity Canine,Human,Mouse,Rabbit
    Format Semi-purified
    Host Species Mouse
    Immunogen Immunization of mice with HUVEC
    Isotype IgG1
    Quantity 100μg
    Regulatory Status RUO
    Research Discipline Cell Structure
    Primary or Secondary Primary
    Monoclonal or Polyclonal Monoclonal

    MUC18 antigen (CD146), a member of the immuoglobulin superfamily, is an intrinsic membrane glycoprotein of 110-120 kDa found on the surface of endothelial cells, bone marrow fibroblasts and various melanomas. MUC18 has been used as a marker of tumor progression in human melanoma because expression in those tumors correlates strongly with poor prognosis and the development of metastic disease. In addition, a number of human T, B and myeloid leukemic cell lines seem to express MUC18. The close structural relationship with N-CAM and related molecules suggests that MUC18 may be also a developmentally regulated cell adhesion molecule (Melanoma adhesion molecule or MCAM).

    ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blotting

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