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MCM4, Rabbit, Monoclonal Antibody, Abnova™
Rabbit monoclonal antibody raised against a human MCM4 peptide using ARM Technology.
Supplier: Abnova Corporation H00004173K
Includes: Up to three rabbit IgG clones of 1mg each will be delivered to customer.
Description
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq
Library Construction: Nonfusion antibody library from rabbit spleen (ARM Technology)Expression: Overexpression vector and transfection into 293H cell line
Order Info
- Customer may provide cell or tissue lysate for antibody screening.
- Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
Specifications
MCM4 | |
Monoclonal | |
Unconjugated | |
In 1X PBS, pH 7.4 | |
MCM4 | |
MCM4 | |
A synthetic peptide of human MCM4 | |
RUO | |
4173 | |
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. | |
IgG |
ELISA, Western Blot | |
1mg | |
minichromosome maintenance complex component 4 | |
MCM4 | |
CDC21, CDC54, MGC33310, P1-CDC21, hCdc21 | |
Rabbit | |
1 mg x up to 3 Abs | |
Primary | |
Human | |
Liquid |
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