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MEK2 Mouse, Unlabeled, Clone: 96/MEK2, BD

Catalog No. BDB610236 Shop All BD Biosciences Products
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BDB610236 150 μg
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Catalog No. BDB610236 Supplier BD Biosciences Supplier No. 610236

Description

Mouse Monoclonal Antibody

MEK (Map/Erk Kinase) 1 and 2 are serine/threonine kinases, also known as MAP kinase kinases (MAP2K1 and 2, MAPKK1 and 2, or MKK1 and 2). They activate the MAP (Mitogen-Activated Protein) kinases, also known as ERKs (Extracellular signal Regulated Kinases), which are critical kinases in multiple signal transduction pathways that regulate cell growth and differentiation. Activation of MEK 1 and 2 is dependent upon phosphorylation of serines 218 and/or 222 by activated MAP kinase kinase kinases (MAP3Ks), such as the Raf isoforms. Hormones, growth and differentiating factors, or tumor promoters induce Raf activation via activation of Ras proteins. MEK2 is seven amino acids larger and shares 81% identity with MEK1. In cultured cells, MEK2 is activated by serum. In vitro, v-Raf phosphorylates and activates MEK2. It is thought that all of these activated protein kinases are downstream of the Ras signal transduction pathway and represent an integral part of the Ras mitogenic signal.

The 96/MEK2 monoclonal antibody recognizes MEK2, regardless of phosphorylation status.

This antibody is routinely tested by western blot analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

TRUSTED_SUSTAINABILITY

Specifications

Antigen MEK2
Applications Western Blot
Classification Monoclonal
Clone 96/MEK2
Concentration 250μg/mL
Conjugate Unconjugated
Description MAP Kinase Kinase 2; ERK Kinase
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Purification Method Affinity Purified
Quantity 150 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Chicken, Frog, Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG2a
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For Research Use Only.

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