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MEK5 Mouse, Unlabeled, Clone: 21, BD

Catalog No. BDB610956 Shop All BD Biosciences Products
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BDB610956 50 μg
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Catalog No. BDB610956 Supplier BD Biosciences Supplier No. 610956

Description

Mouse Monoclonal Antibody

The mitogen-activated protein (MAP) kinase cascade participates in the Ras signal transduction pathway. The MAP kinase cascade consists of MEK kinase (Raf-1 or B-Raf), MAP/ERK kinase (MEK1 or MEK2), and extracellular-regulated protein kinase (ERK1 or ERK2). Raf becomes activated following its interaction with Ras-GTP (activated Ras). Via phosphorylation reactions, Raf activates MEK which, in turn, activates ERK. MEK5, also known as MAP Kinase 5, is a 50kDa protein that is 40% identical to MEK1 and MEK2. Alternative splicing results in two MEK5 isoforms: α (50kDa) and β (40kDa). MEK5β has been reported to be ubiquitously expressed while MEK5α is expressed primarily in the liver and brain. The N-terminal amino acid sequence of MEK5α resembles sequences found in actin cytoskeletal proteins, indicating that MEK5α may associate with the cytoskeleton. However, the role of MEK5 in the MAP kinase pathway and its substrate remain to be identified.

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen MEK5
Applications Western Blot
Classification Monoclonal
Clone 21
Concentration 250μg/mL
Conjugate Unconjugated
Description MAP Kinase-5
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human MEK5 aa. 13-188
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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For Research Use Only.

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